Rectal Wall vs. Whole Rectum Dose: Which Volume Better Predicts Gastrointestinal Toxicity from Prostate External Beam Radiotherapy?
نویسندگان
چکیده
منابع مشابه
Delivered dose can be a better predictor of rectal toxicity than planned dose in prostate radiotherapy
BACKGROUND AND PURPOSE For the first time, delivered dose to the rectum has been calculated and accumulated throughout the course of prostate radiotherapy using megavoltage computed tomography (MVCT) image guidance scans. Dosimetric parameters were linked with toxicity to test the hypothesis that delivered dose is a stronger predictor of toxicity than planned dose. MATERIAL AND METHODS Dose-s...
متن کاملPrediction of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer
BACKGROUND Gastrointestinal (GI) toxicity is a common effect following radiation therapy (RT) for prostate cancer. Purpose of the present work is to compare two Normal Tissue Complication Probability (NTCP) modelling approaches for prediction of late radio-induced GI toxicity after prostate external beam radiotherapy. METHODS The study includes 84 prostate cancer patients evaluated for late r...
متن کاملThe effect of Rectal Retractor, a rectal protector on rectal dose in radical prostate radiotherapy
Introduction: The close proximity of the rectum tissue to the prostate gland results in rectal toxicity during prostate radiotherapy. Rectal Retractor (RR) is a rectal displacement technique that inserts into the rectum, as a result, the lateral and dorsal part of the rectal wall push away from high dose areas. The aim of this study was to investigate the dosimetric consequence...
متن کاملDefining a dose-response relationship for prostate external beam radiotherapy.
INTRODUCTION We aimed to quantify a relationship between radiotherapy dose and freedom from biochemical failure (FFBF) in low- and intermediate-risk prostate cancer. To reduce confounding we used data with a standardised end-point, mature follow-up, low competing risk of metastatic failure, conventional fractionation and separate reporting for outcomes with hormonal therapy (HT). METHODS A sy...
متن کاملProstate external beam radiotherapy combined with high-dose-rate brachytherapy: dose-volume parameters from deformably-registered plans correlate with late gastrointestinal complications
BACKGROUND Derivation of dose-volume correlated with toxicity for multi-modal treatments can be difficult due to the perceived need for voxel-by-voxel dose accumulation. With data available for a single-institution cohort with long follow-up, an investigation was undertaken into rectal dose-volume effects for gastrointestinal toxicities after deformably-registering each phase of a combined exte...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Radiation Oncology*Biology*Physics
سال: 2019
ISSN: 0360-3016
DOI: 10.1016/j.ijrobp.2019.06.1822